Five-Year Survival  90 to 95 percent 

Investigational 
• Prophylactic chemotherapy .

Stage III 
TNM Any T, any N, M1 
The tumor invades other organs, most commonly the lungs or lymph nodes above the diaphragm.

Standard Treatment  Radical orchiectomy followed by chemotherapy for both seminoma and non-seminomatous tumors.
    The most frequently used drug combinations are cisplatin and etoposide (EP), each day for five consecutive days repeated every three weeks for four doses or cycles, or BEP, which uses the same doses and schedule of five days but adds bleomycin weekly for three cycles.
    Fluids are given by vein to prevent cisplatin-induced kidney toxicity. Drugs are given by the same route to stop or minimize nausea and vomiting. A total of three to four cycles are given at no more than three- to four-week intervals, since it is harmful to space therapy at longer intervals. Only complete response is acceptable, and surgery is required when CT scans of the chest, abdomen and pelvis find any remaining disease, indicating a partial response.